I am somewhat late posting this one, however as talked about within the remark part of my Mid-12 months replace, I did add Aerovate Therapeutics (AVTE) ($55MM market cap) to my damaged biotech basket. Again in June, Aerovate, a one-shot-on-goal biotech, introduced poor topline outcomes from the Part 2b portion of their AV-101 examine for the remedy of pulmonary arterial hypertension (PAH). A number of weeks later, the corporate introduced they have been shedding 78% of their workers, costing them $5.6MM, $3MM of which is able to hit in Q3 and This autumn. Then one other week later, AVTE formally introduced they have been exploring strategic alternate options:
Aerovate has engaged Wedbush PacGrow as the corporate’s unique strategic monetary advisor to help within the means of exploring strategic alternate options, which can embrace however should not restricted to, an acquisition, merger, reverse merger, enterprise mixture, liquidation or different transaction.
Notably, they listed a liquidation as a doable consequence, typically we do not see a liquidation known as out within the preliminary strategic alternate options announcement. One cause is likely to be they haven’t any different product candidates, from their newest 10-Q:
Overview
We’re a biopharmaceutical firm. Our preliminary focus was on advancing AV 101, our dry powder inhaled formulation of imatinib for the remedy of pulmonary arterial hypertension, or PAH, a devastating illness impacting roughly 70,000 individuals in america and Europe. On June 17, 2024, we introduced topline outcomes from the Part 2b portion of our Part 2b/Part 3 Inhaled Imatinib Pulmonary Arterial Hypertension Scientific Trial of AV-101, or IMPAHCT. Topline knowledge confirmed that, whereas AV-101 was typically properly tolerated throughout all dose teams, the examine didn’t meet its major endpoint for enchancment in pulmonary vascular resistance in comparison with placebo for any of the studied doses or present significant enhancements within the secondary endpoint of change in six minute stroll distance. We additionally reviewed knowledge from a number of extra secondary endpoints of the Part 2b portion of IMPAHCT, which additionally failed to point out significant enhancements. Primarily based upon these outcomes and in settlement with the impartial examine advisory committee, we halted enrollment and shut down the Part 3 portion of IMPAHCT in addition to the long-term extension examine. AV-101 for the remedy of PAH was our solely product candidate in improvement. At the moment, we don’t intend to renew improvement of AV-101 or every other product candidates. In July 2024, we introduced the choice to conduct a complete overview of strategic alternate options centered on maximizing shareholder worth. We additionally engaged Wedbush Securities Inc. (Wedbush PacGrow) as our unique strategic monetary advisor to help within the means of exploring strategic alternate options, which can embrace however should not restricted to, an acquisition, merger, reverse merger, enterprise mixture, liquidation or different transaction.
I am nonetheless attempting to get my arms round how the brand new SEC shell firm rule goes to play out after going efficient July 1, 2024, however it seems that these one-shot-on-goal sort biotechnology corporations, like AVTE, with out different belongings may fall into the shell firm bucket and might be pushed in direction of a liquidation consequently. Others which might be persevering with improvement similtaneously pursuing strategic alternate options may make for higher reverse merger candidates, which have typically labored out properly this yr. However I am not a lawyer, and thus not fully positive if this new rule means a lot to this a part of the market since biotechs typically do not make outlandish SPAC-like income projections regulators try to stamp out. If others have extra clever ideas, as normal please share.
My again of envelope liquidation math:
AVTE is fairly clear, there are minimal dilutive securities excellent, minimal working lease remaining and sure the IP worth is nugatory. I nonetheless battle a bit with estimating wind down bills, be happy to make use of your personal estimate, however at as we speak’s worth, AVTE appears to be comparatively low cost in comparison with my estimate of liquidation worth.
In the event that they do go the reverse merger route, there’s some good choice worth, curiously RA Capital owns ~32% of AVTE and engineered a profitable reverse merger at ELYM with Tenet Medicines that is seen the inventory go up nearly 200% since that deal was introduced in April.
Disclosure: I personal shares of AVTE
